Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma
| Autor: | David P. Martin, Darrell R. Schroeder, James J. Butz, Toby N. Weingarten, Travis J. McKenzie, William F. Young, Alexandre N. Cavalcante, Irina Bancos, Juraj Sprung |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adrenal Gland Neoplasms 030232 urology & nephrology Diastole Hemodynamics Blood Pressure Pheochromocytoma Paraganglioma Intraoperative Period 03 medical and health sciences 0302 clinical medicine Interquartile range Diabetes mellitus medicine Humans Vasoconstrictor Agents Postoperative Period Enzyme Inhibitors Propensity Score Retrospective Studies Phenoxybenzamine business.industry Acute kidney injury General Medicine Perioperative Middle Aged medicine.disease Treatment Outcome alpha-Methyltyrosine Blood pressure 030220 oncology & carcinogenesis Anesthesia Drug Therapy Combination Female Laparoscopy Surgery business |
| Zdroj: | International Journal of Surgery. 46:1-6 |
| ISSN: | 1743-9191 |
| DOI: | 10.1016/j.ijsu.2017.08.026 |
| Popis: | Introduction To describe outcomes of patients with metyrosine (MET) pretreatment for abdominal surgical resection of pheochromocytoma or paraganglioma (PCC/PGL) compared with patients who had phenoxybenzamine (PBZ) pretreatment. Methods Retrospective review of perioperative outcomes for PCC/PGL patients treated with MET and propensity-matched comparison of MET and PBZ (MET + PBZ) with PBZ alone. Results MET preparation was given in 63 cases (26 laparoscopic and 37 open, of which 55 also received PBZ). All patients had wide perioperative hemodynamic oscillations. Patients with open procedures required more intravenous fluids and blood transfusions; 35% required postoperative vasopressor infusions for hypotension and 38% developed acute kidney injury. One laparoscopic procedure required postoperative vasopressor infusion, and 12% of patients developed acute kidney injury. Forty-five MET + PBZ patients were propensity-matched with PBZ-only patients. Intraoperatively, MET + PBZ patients had lower minimum systolic and diastolic blood pressures than PBZ-only patients (median systolic, 74 vs 80 mm Hg, P = 0.01; median diastolic, 42 vs 46 mm Hg, P = 0.005) and larger intraoperative blood pressure oscillations (median systolic range, 112 vs 93 mm Hg, P = 0.06; median diastolic range, 58 vs 51 mm Hg, P = 0.02). Postoperative vasopressor infusion use was similar between MET + PBZ and PBZ only (16% vs 11%, P = 0.76). Major outcomes were not different between regimens. Conclusion Large hemodynamic oscillations were present in our PCC/PGL patients treated with MET + PBZ. These patients had a wider range of intraoperative blood pressure variations than PBZ-only patients. No differences in postoperative comorbid outcomes were found between MET + PBZ and PBZ-only groups. |
| Databáze: | OpenAIRE |
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