Hypoglycaemic effect of resveratrol in streptozotocin-induced diabetic rats is impaired when supplemented in association with leucine
| Autor: | José Henrique Leal Cardoso, Ariclécio Cunha de Oliveira, Ewerton Sousa de Abreu, Edivânia Oliveira Bezerra Pontes, Leonardo R. Silveira, Denise P. Carvalho, Everardo M. Carneiro, Francisco Leonardo Torres Leal, Renata Prado Vasconcelos, Liohanna Silva Pires D Avila, Andrelina Noronha Coelho de Souza, Jessica de Freitas Nascimento, Keciane Alves de Oliveira, Sarah Rickli |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Adipose Tissue White Adipose tissue 030209 endocrinology & metabolism Resveratrol Antioxidants Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Leucine Internal medicine Diabetes mellitus Adipocytes medicine Animals Hypoglycemic Agents Insulin Drug Interactions Adiposity 030109 nutrition & dietetics business.industry Streptozotocin medicine.disease Rats Endocrinology Adipose Tissue chemistry Fruit Dietary Supplements Insulin Resistance business Phytotherapy Food Science medicine.drug |
| Zdroj: | International Journal of Food Sciences and Nutrition. 71:529-539 |
| ISSN: | 1465-3478 0963-7486 |
| Popis: | Studies have shown synergistic and independent effects of leucine and resveratrol (RSV) as possible therapeutic agents to ameliorate metabolic disorders. Thus, the objective of this study was to investigate the effects of supplementation with leucine and RSV, alone and in combination, on metabolic changes in white adipose tissue of neonatally STZ-induced diabetic rats. After weaning, the rats were treated with trans-resveratrol (0.6 mg/kg/dose) and/or leucine (1.35 mg/kg/dose) administered orally. The animals were euthanized at age 16 weeks for blood analyses. Subcutaneous (SC), periepididymal (PE) and retroperitoneal (RP) fat pads were weighed. Adipocytes from PE and RP pads were isolated for morphometric analysis. Long-term supplementation with RSV promoted adiposity recovery, prevented hypoinsulinemia and improved the metabolic profile of the diabetic rats. However, some of these effects were impaired when RSV was associated with leucine. The diabetic rats supplemented with leucine alone showed no significant improvement in metabolic disorders. |
| Databáze: | OpenAIRE |
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