Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction
Autor: | Raluca Maria Pop, Paul-Mihai Boarescu, Ioana Corina Bocșan, Dan Gheban, Ioana Chirila, Adriana Elena Bulboacă, Sorana D. Bolboacă |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Aging
Curcumin Antioxidant Article Subject medicine.medical_treatment Myocardial Infarction Pharmacology Creatine medicine.disease_cause Biochemistry Antioxidants chemistry.chemical_compound Animals Medicine Myocardial infarction Rats Wistar lcsh:QH573-671 business.industry lcsh:Cytology Anti-Inflammatory Agents Non-Steroidal Isoproterenol Cell Biology General Medicine Adrenergic beta-Agonists medicine.disease Rats Oxidative Stress Cytokine Interstitial edema chemistry Nanoparticles Female Myocardial necrosis business Oxidative stress Research Article |
Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity |
ISSN: | 1942-0900 |
DOI: | 10.1155/2019/7847142 |
Popis: | Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wistar-Bratislava white rats were randomly divided into eight groups of seven rats each. Curcumin and curcumin nanoparticles were given by gavage in three different doses (100 mg/kg body weight (bw), 150 mg/kg bw, and 200 mg/kg bw) for 15 days. The MI was induced on day 13 using 100 mg/kg bw ISO administered twice, with the second dose 24 h after the initial dose. The blood samples were taken 24 h after the last dose of ISO. The antioxidant, anti-inflammatory, and cardioprotective effects were evaluated in all groups. All doses of CC and CCNP offered a cardioprotective effect by preventing creatine kinase-MB leakage from cardiomyocytes, with the best result for CCNP. All the oxidative stress parameters were significantly improved after CCNP compared to CC pretreatment. CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels (such as TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES) after MI. MMP-2 and MMP-9 levels decreased more after pretreatment with CCNP than with CC. CCNP better prevented myocardial necrosis and reduced interstitial edema and neutrophil infiltration than CC, on histopathological examination. Therefore, improving the bioactivity of curcumin by nanotechnology may help limit cardiac injury after myocardial infarction. |
Databáze: | OpenAIRE |
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