Vaccination status and COVID-19 related mortality: A hospital based cross sectional study
| Autor: | Sridhar Mangalesh, Mrinalini Koley, J. Muthukrishnan, Arun Kumar Yadav, Subramanian Shankar, Anurag Khera, Vasu Vardhan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Cross sectional study Cross-sectional study business.industry Vaccination COVISHIELD General Medicine Odds ratio Hospital based Logistic regression Odds Clinical trial Internal medicine medicine Original Article Predictors of Mortality Covid-19 business |
| Zdroj: | Medical Journal, Armed Forces India |
| ISSN: | 0377-1237 |
| DOI: | 10.1016/j.mjafi.2021.06.034 |
| Popis: | Background Efficacy of vaccines studied in clinical trial settings are likely to be different from their effectiveness in a real-world scenario. Indian Armed Forces launched its vaccine drive against COVID-19 on 16 Jan 2021. This study evaluated the effect of vaccination on mortality amongst hospitalized COVID patients. Methods A cross sectional study was done on all admitted moderate to severe COVID-19 patients at a designated COVID hospital in New Delhi. The primary outcome assessed the association of being fully vaccinated with mortality. Unadjusted odds ratios (OR) (with 95% CI) was performed for each predictor. Logistic regression was used for multivariable analysis and adjusted odds ratios obtained. Results The 1168 patients included in the study had a male preponderance with a mean age of 54.6 (± 17.51) years. A total of 266 (23%) patients were partially vaccinated with COVISHIELD® and 184 (16%) were fully vaccinated. Overall, 518 (44.3%) patients had comorbidities and 332 (28.4%) died. Among those fully vaccinated, there was 12.5% (23/184) mortality while it was 31.45 % (309/984) among the unvaccinated (OR 0.3, 95% CI 0.2 to 0.5, p |
| Databáze: | OpenAIRE |
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