Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Autor: Fanciulli, Chiara, Berenguer, Juan, Busca, Carmen, Vivancos, María J, Téllez, María J, Domínguez, Lourdes, Domingo, Pere, Navarro, Jordi, Santos, Jesús, Iribarren, José A, Morano, Luis, Artero, Arturo, Moreno, Javier, Rivero-Román, Antonio, Santos, Ignacio, Giner, Livia, Armiñanzas, Carlos, Montero, Marta, Manzardo, Christian, Cifuentes, Carmen, García, Coral, Galindo, María J, Ferrero, Oscar L, Sanz, José, de la Fuente, Belén, Rodríguez, Carmen, Gaspar, Gabriel, Pérez, Laura, Losa, Juan E, Force, Luis, Veloso, Sergio, Martínez-Alfaro, Elisa, Jarrin-Vera, Inmaculada, De Miguel, Marta, González Garcia, Juan, GeSIDA 8514 Study Group
Přispěvatelé: Instituto de Salud Carlos III, Red de Investigación Cooperativa en Investigación en Sida, Plan Nacional de I+D+i (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Universidad de Cantabria, Institut Català de la Salut, [Fanciulli C, Berenguer J] Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain. Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. [Busca C] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. [Vivancos MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Ramón y Cajal (Irycis), Madrid, Spain. [Téllez MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Clínico San Carlos, Madrid, Spain. [Domínguez L] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain. [Navarro J] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2022
Předmět:
Liver Cirrhosis
Hepatitis C - Epidemiologia
HIV Infections
Hepatitis C/drug therapy/epidemiology
Hepacivirus
Virus Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases
Viral::HIV Infections [DISEASES]
Antiviral Agents
HIV infection/*epidemiology
coinfection/*epidemiology
Humans
Coinfection/epidemiology
hepatitis C/drug therapy/*epidemiology
Pharmacology (medical)
Virus Diseases::Coinfection [DISEASES]
Coinfection
Health Policy
virosis::coinfección [ENFERMEDADES]
virosis::hepatitis viral humana::hepatitis C [ENFERMEDADES]
virus diseases
Virus Diseases::Hepatitis
Viral
Human::Hepatitis C [DISEASES]
Hepatitis C
Chronic
Hepatitis C/drug Therapy/*epidemiology
Hepatitis C
Infeccions per VIH - Epidemiologia
Coinfection/*epidemiology
Infectious Diseases
Spain
RNA
virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH [ENFERMEDADES]
Zdroj: Repisalud
Instituto de Salud Carlos III (ISCIII)
HIV Med . 2022 Aug;23(7):705-716
Scientia
Popis: Epidemiology; HIV/HCV coinfection; Spain Epidemiologia; Coinfecció pel VIH/VHC; Espanya Epidemiologia; Coinfección por el VIH/VHC; España Objectives We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015–2018. Methods The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population. This work was supported in part by the Spanish AIDS Research Network (RD16/0025/0017, RD16/0025/0018), which is included in the Spanish I+D+I Plan and is co-funded by the ISCIII-Subdirección General de Evaluación and European Funding for Regional Development (FEDER). The sponsors had no role in the study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the article for publication.
Databáze: OpenAIRE
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