Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Headaches:A Randomized Clinical Trial
| Autor: | Hande Coskun, Roberto De Icco, Cristina Lopez-Lopez, Josefin Snellman, Lanfranco Pellesi, Messoud Ashina, Faisal Mohammad Amin, Mohammad Al-Mahdi Al-Karagholi, Fatima Azzahra Elbahi, Jens Hannibal |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Vasoactive intestinal peptide Area under the curve General Medicine medicine.disease Placebo Crossover study law.invention Migraine Randomized controlled trial law Internal medicine medicine International Classification of Headache Disorders Headaches medicine.symptom business |
| Zdroj: | Pellesi, L, Al-Karagholi, M A M, De Icco, R, Coskun, H, Elbahi, F A, Lopez-Lopez, C, Snellman, J, Hannibal, J, Amin, F M & Ashina, M 2021, ' Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Headaches : A Randomized Clinical Trial ', JAMA network open, vol. 4, no. 8, e2118543 . https://doi.org/10.1001/jamanetworkopen.2021.18543 |
| Popis: | Importance: Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) are structurally and functionally related, yet different in their migraine-inducing properties. It remains unclear whether the lack of migraine induction can be attributed to the only transient vasodilatory response after a 20-minute infusion of VIP. Objective: To determine whether a 2-hour infusion of VIP would provoke migraine attacks. Design, Setting, and Participants: A randomized, double-blind, placebo-controlled, crossover study was conducted between May and September 2020 at the Danish Headache Center in Copenhagen, Denmark. Patients were eligible for inclusion if they were ages 18 to 40 years, weighed between 50 and 90 kg, had a diagnosis of migraine without aura as defined by the International Classification of Headache Disorders, and had a migraine frequency of 1 to 6 attacks per month. Interventions: Patients were randomly allocated to receive a 2-hour infusion of VIP or placebo on 2 different days. Main Outcomes and Measures: The primary end point was the difference in incidence of experimentally induced migraine attacks during the observational period (0-12 hours) between VIP and placebo. Results: Twenty-one patients (17 [81%] women and 4 [19%] men; mean [range] age, 25.9 [19-40] years) were recruited in the study. Fifteen patients (71%; 95% CI, 48%-89%) developed migraine attacks after VIP compared with 1 patient (5%; 95% CI, 0%-24%) who developed a migraine attack after placebo (P 0-12h, P =.003; AUC0-180min, P |
| Databáze: | OpenAIRE |
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