Methamphetamine-induced neuronal necrosis: the role of electrographic seizure discharges

Autor:	Emil S. Pais, Muhammad Tariq Bashir, Kung-Chiao Hsieh, Ernesto R. Aviles, Denson G. Fujikawa
Rok vydání:	2016
Předmět:	Male 0301 basic medicine Pathology medicine.medical_specialty Excitotoxicity Hippocampal formation Toxicology medicine.disease_cause Amygdala Article Body Temperature Methamphetamine Mice Necrosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Seizures Piriform cortex medicine Animals Neurons business.industry General Neuroscience Brain Electroencephalography Meth Entorhinal cortex 030104 developmental biology medicine.anatomical_structure nervous system chemistry Forelimb business Neuroscience 030217 neurology & neurosurgery medicine.drug
Zdroj:	NeuroToxicology. 52:84-88
ISSN:	0161-813X
DOI:	10.1016/j.neuro.2015.11.001
Popis:	We have evidence that methamphetamine (METH)-induced neuronal death is morphologically necrotic, not apoptotic, as is currently believed, and that electrographic seizures may be responsible. We administered 40 mg/kg i.p. to 12 male C57BL/6 mice and monitored EEGs continuously and rectal temperatures every 15 min, keeping rectal temperatures
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8809855b819622a7009d0d48fe3790bf https://doi.org/10.1016/j.neuro.2015.11.001 Zobrazit plný text záznamu Full Text from ScienceDirect