Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues
| Autor: | Eduardo Dunayevich, Frank Telang, Gene-Jack Wang, Elisabeth de Castro Caparelli, Dardo Tomasi, Nora D. Volkow, Ruiliang Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Leptin medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Hypothalamus Medicine (miscellaneous) Appetite Stimulation Hippocampal formation bupropion Naltrexone Dopamine Uptake Inhibitors Internal medicine Weight Loss medicine Humans Peptide YY Obesity Meals media_common Bupropion Nutrition and Dietetics medicine.diagnostic_test business.industry fMRI Magnetic Resonance Imaging Ghrelin Diet Endocrinology Treatment Outcome Original Article Drug Therapy Combination Female Cues Functional magnetic resonance imaging business Insula medicine.drug |
| Zdroj: | International Journal of Obesity (2005) |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Objective: The significant weight loss observed with combination naltrexone-sustained release (SR) 32 mg and bupropion SR 360 mg (NB32) therapy is thought to be due, in part, to bupropion stimulation of hypothalamic pro-opiomelanocortin (POMC) neurons, and naltrexone blockade of opioid receptor-mediated POMC autoinhibition, but the neurobiological mechanisms are not fully understood. We assessed changes in brain reactivity to food cues before and after NB32 treatment. Methods: Forty women (31.1±8.1 years; body mass index: 32.5±3.9) received 4 weeks of NB32 or placebo, and were instructed to maintain their dietary and exercise habits. Functional magnetic resonance imaging responses (analyzed using SPM2 and clusters (>100 pixels)) to a 5-min food video (preparation of the subject's favorite food) and a 5-min neutral video (manipulation of neutral objects) under conditions of mild food deprivation (∼14 h) were assessed before and after treatment. Results: The food cues video induced positive brain activation in visual and prefrontal cortices, insula and subcortical brain regions. The group-by-treatment interaction on regional brain activation was significant and showed that whereas NB32 attenuated the activation in the hypothalamus in response to food cues (P |
| Databáze: | OpenAIRE |
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