NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis
| Autor: | Olivia Lutz, Neeraj Tandon, Balaji Narayanan, James L. Reilly, Sarah K. Keedy, Deepthi Bannai, Jonathan Spring, Matcheri S. Keshavan, Huma Asif, Tamar A. Grey, Katherine Reis, Chunyu Liu, Jeffrey R. Bishop, Lucas Coppes, John A. Sweeney, Scot Hill, Victor Zeng, Brett A. Clementz, Judith L. Rapoport, Rebekka Lencer, Jaya Padmanabhan, Carol A. Tamminga, Uzma Nawaz, Shashwath A. Meda, Siyuan Liu, Judith A. Badner, Madeline Klinger, Steven A. McCarroll, Peter F. Buckley, Godfrey D. Pearlson, Philip Henson, Diane Gage, Nicolas R. Bolo, Rebecca Shafee, Ney Alliey-Rodriguez, David Curtis, Dung T. Hoang, Elliot S. Gershon, David C. Glahn, Elena I. Ivleva, Rachal Hegde |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Psychosis Pathology medicine.medical_specialty Microarray Genotype Genome-wide association study Neuroimaging Biology Molecular neuroscience Polymorphism Single Nucleotide Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Lateral ventricles Young Adult 0302 clinical medicine Lateral Ventricles medicine SNP Humans Clinical genetics 1000 Genomes Project Allele Neural Cell Adhesion Molecules lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Alleles Calcium-Binding Proteins Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health 030104 developmental biology Psychotic Disorders Choroid plexus Female 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Translational Psychiatry, Vol 9, Iss 1, Pp 1-7 (2019) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Schizophrenia, Schizoaffective, and Bipolar disorders share behavioral and phenomenological traits, intermediate phenotypes, and some associated genetic loci with pleiotropic effects. Volumetric abnormalities in brain structures are among the intermediate phenotypes consistently reported associated with these disorders. In order to examine the genetic underpinnings of these structural brain modifications, we performed genome-wide association analyses (GWAS) on 60 quantitative structural brain MRI phenotypes in a sample of 777 subjects (483 cases and 294 controls pooled together). Genotyping was performed with the Illumina PsychChip microarray, followed by imputation to the 1000 genomes multiethnic reference panel. Enlargement of the Temporal Horns of Lateral Ventricles (THLV) is associated with an intronic SNP of the gene NRXN1 (rs12467877, P = 6.76E–10), which accounts for 4.5% of the variance in size. Enlarged THLV is associated with psychosis in this sample, and with reduction of the hippocampus and enlargement of the choroid plexus and caudate. Eight other suggestively significant associations (P |
| Databáze: | OpenAIRE |
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