The Effect of Cimetidine on Serum Concentrations of Piroxicam
| Autor: | Stephen L. Dahl, Claude Mailhot, John R. Ward |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Oral dose medicine.medical_specialty Metabolic Clearance Rate Thiazines Pharmacology Piroxicam Gastroenterology Pharmacokinetics Internal medicine medicine Humans Drug Interactions Pharmacology (medical) Cimetidine business.industry Anti-Inflammatory Agents Non-Steroidal Elimination kinetics Serum concentration Kinetics business Half-Life medicine.drug |
| Zdroj: | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 6:112-117 |
| ISSN: | 0277-0008 |
| DOI: | 10.1002/j.1875-9114.1986.tb03464.x |
| Popis: | To evaluate the effect of cimetidine on serum concentrations of piroxicam, we administered a single 20-mg oral dose of piroxicam to 10 healthy male volunteers on 2 occasions. The first was given on day 1 of the study and the second on day 15, 7 days after starting cimetidine 300 mg orally 4 times a day. Nineteen blood samples were drawn for 7 days after each piroxicam dose to characterize its pharmacokinetics. Piroxicam was analyzed by high-performance liquid chromatography. The mean piroxicam elimination rate constants (Kel), elimination half-lives, and area under the serum concentration-time curves (AUC) were as follows (mean +/- standard deviation): (formula; see text) Data were analyzed with a Wilcoxon matched-pairs, signed-ranks, two-tailed statistical test. Although the increase in AUC was statistically significant, it was of low amplitude (mean 15%) and is probably not clinically significant. The results of this study suggest that cimetidine does not significantly alter the elimination kinetics of a single dose of piroxicam in young healthy males. Additional investigation is needed to confirm these findings in other patient populations. |
| Databáze: | OpenAIRE |
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