Interleukin-6, tumor necrosis factor-α, C-reactive protein, and hematological parameters in experimental periodontal disease after β-adrenergic blockade
| Autor: | Carlos Antonio Trindade da Silva, Camila Botelho Miguel, Carlo José Freire Oliveira, Carlos Ueira Vieira, Juliana Trindade Clemente-Napimoga, Wellington Francisco Rodrigues, Marcelo Henrique Napimoga, Javier Emilio Lazo-Chica |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Propranolol C-reactive protein 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine vascular lesions Periodontal disease Internal medicine Medicine Interleukin 6 Tumor necrosis factor α Pathological experimental periodontitis Periodontitis biology business.industry 030206 dentistry medicine.disease cytokines lcsh:RK1-715 Cytokine Endocrinology lcsh:Dentistry biology.protein Adrenergic system Periodontics Original Article business medicine.drug |
| Zdroj: | Journal of Indian Society of Periodontology Journal of Indian Society of Periodontology, Vol 23, Iss 6, Pp 511-516 (2019) |
| ISSN: | 0972-124X |
| DOI: | 10.4103/jisp.jisp_77_19 |
| Popis: | Background: Changes in the levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) observed during periodontal disease were linked with vascular manifestations. Recent studies showed that the beta-blocker propranolol reduces the pathological parameters associated with certain molecules at sites of bone injury. Hence, in this study, we evaluated the activity of propranolol on hematological parameters and systemic concentrations of inflammatory proteins in a model of experimental periodontitis. Materials and Methods: Periodontal disease was induced in rats. After euthanasia, the number of inflammatory cells in each rat was quantified using histopathological assays. In addition, hematological parameters were quantitated using automated analysers, cytokine levels were determined using an enzyme-linked immunosorbent assay, and CRP levels were determined using a high-sensitivity immunoturbidimetric assay. Results: Low doses of propranolol suppressed the systemic production of CRP, TNF-α, and IL-6; however, the hematological parameters were not affected. Conclusions: β-adrenergic activation indirectly contributes to the pattern of systemic inflammatory molecules observed in periodontal disease. These molecules may initiate cardiovascular diseases as a consequence of periodontitis. |
| Databáze: | OpenAIRE |
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