Prognostic factors in granulosa-cell tumors
| Autor: | Claes Silfverswärd, Elisabet Björkholm |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Oncology endocrine system medicine.medical_specialty Adolescent medicine.medical_treatment Mitosis Internal medicine medicine Carcinoma Humans Nuclear atypia Stage (cooking) Aged Granulosa Cell Tumor Neoplasm Staging Cell Nucleus Ovarian Neoplasms Sweden business.industry Obstetrics and Gynecology Middle Aged Prognosis medicine.disease Granulosa cell tumors Radiation therapy Tumor rupture Concomitant Mitotic Figure Female business |
| Zdroj: | Gynecologic Oncology. 11:261-274 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/0090-8258(81)90040-8 |
| Popis: | A histological reevaluation was performed on 198 women with granulosa- and granulosa-theca-cell tumors treated at Radiumhemmet 1923–1972. Ninety-one percent of the patients were of clinical stage I (FIGO). The mean age at diagnosis was 52.6 years. All patients underwent surgery and all but 11% received complementary radiotherapy. Concomitant endometrial carcinoma was found in 6%. At the follow-up (1977–1978) 42 women had died from their granulosa-cell tumor. Advanced clinical stage, the presence of tumor rupture and pronounced nuclear atypia were associated with a poor prognosis. A high number of mitotic figures were of prognostic value only in stages II–IV. In stage I tumor size was related to outcome. The histological pattern of the granulosa-cell component was of no prognostic value. |
| Databáze: | OpenAIRE |
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