Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers
| Autor: | Catherine Féart, Stefan Walter, Roger H. K. Morris, Perrine André, Karine Pérès, Leocadio Rodríguez-Mañas, Jean-François Dartigues, Lee Butcher, Jorge D. Erusalimsky |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gerontology Eotaxin Chemokine CCL11 Male Rural Population Aging Urban Population Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Cognition Genetics Cognitive status Medicine Humans Cognitive Dysfunction Association (psychology) Cognitive impairment Molecular Biology Geriatric Assessment CCL11 Aged Aged 80 and over business.industry Cell Biology Mental Status and Dementia Tests 030104 developmental biology Cross-Sectional Studies Logistic Models Ageing Cohort Multivariate Analysis Female France Independent Living business 030217 neurology & neurosurgery |
| Zdroj: | Experimental gerontology. 113 |
| ISSN: | 1873-6815 |
| Popis: | The chemokine CCL11 has been implicated in age-related cognitive deterioration in mice, yet evidence on the relationship between CCL11 and cognitive function in humans is limited. This study explored associations between CCL11 and cognition in rural and urban community-dwelling older adults. Participants were 515 urban dwellers from the 3C-Bordeaux cohort and 318 rural dwellers from the AMI cohort. Plasma CCL11 was measured using an enzyme-linked immunoassay. Mini Mental State Examination (MMSE) test scores were used as the main measure of cognitive performance. Multivariate regression analysis was used to evaluate the cross-sectional association between CCL11 and cognitive performance. CCL11 was significantly higher in rural dwellers compared to city dwellers (median [IQR]: 145 [115-201] pg/mL vs. 103 [85-129] pg/mL; p 0.001). After adjustment for confounders, CCL11 was found to be negatively associated with cognitive performance in rural dwellers but not in city dwellers. These results suggest that CCL11 may be an independent determinant of cognitive function in older rural dwellers and that the residential environment modifies this association. |
| Databáze: | OpenAIRE |
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