Effects of Optic Neuritis, T2 Lesions, and Microstructural Diffusion Integrity in the Visual Pathway on Cortical Thickness in Pediatric‐Onset Multiple Sclerosis
| Autor: | John R Sollee, Amy Waldman, Amy M. Lavery, Brenda Banwell, Ritobrato Datta, Gabriella Ficerai-Garland, Krystle Karoscik, Geraldine Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Multiple Sclerosis Optic Neuritis Visual acuity Adolescent genetic structures Anterior Visual Pathway 030218 nuclear medicine & medical imaging White matter Lesion Young Adult 03 medical and health sciences 0302 clinical medicine Ophthalmology Fractional anisotropy medicine Humans Visual Pathways Radiology Nuclear Medicine and imaging Optic neuritis Child Visual Cortex business.industry Brain medicine.disease Magnetic Resonance Imaging eye diseases medicine.anatomical_structure Visual cortex Anisotropy Female sense organs Neurology (clinical) medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Neuroimaging. 29:760-770 |
| ISSN: | 1552-6569 1051-2284 |
| DOI: | 10.1111/jon.12654 |
| Popis: | Background and purpose Pediatric-onset multiple sclerosis (POMS) is associated with focal inflammatory lesions and the loss of cortical and deep gray matter. Optic neuritis (ON) and white matter (WM) lesions in the visual pathway can directly contribute to visual cortical mantle thinning. We determine the relative contributions of MS insult on anterior and posterior visual pathway integrity. Methods High- and low-contrast visual acuity, optical coherence tomography (OCT), and 3T MRI scans were obtained from 20 POMS patients (10 with remote ON) and 22 age- and sex-matched healthy controls. Cortical mantle thickness was measured using FreeSurfer. Fractional anisotropy (FA) and mean diffusivity were calculated for postchiasmal optic radiations (with and without WM lesions). Groups were compared using Student's t-test (adjusted for multiple comparisons), and simple linear regression was used to investigate interrelationships between measures. Results Mean cortical thickness of the whole brain was reduced in patients (2.49 mm) versus controls (2.58 mm, P = .0432) and in the visual cortex (2.07 mm vs. 2.17 mm, P = .0059), although the foveal confluence was spared. Mean FA of the optic radiations was reduced in POMS (.40) versus controls (.43, P = .0042) and correlated with visual cortical mantle thickness in POMS (P = .017). Visual acuity, OCT measures, and lesion volumes in the optic radiations were not associated with cortical mantle thickness. Conclusions POMS negatively impacts the integrity of the anterior visual pathway, but it is the loss of WM integrity that drives anterograde loss of the cortical mantle. Preserved visual acuity and foveal sparing imply some degree of functional and structural resilience. |
| Databáze: | OpenAIRE |
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