Berberine acutely activates the glucose transport activity of GLUT1
| Autor: | Alexandra Cok, Daniel S. Oram, Jude Chenge, Larry L. Louters, Matthew J. Salie, Christina Plaisier |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Berberine Pyridines Glucose uptake Stimulation AMP-Activated Protein Kinases Deoxyglucose Biochemistry p38 Mitogen-Activated Protein Kinases Article Cell Line chemistry.chemical_compound Mice AMP-activated protein kinase Internal medicine medicine Animals Enzyme Inhibitors Extracellular Signal-Regulated MAP Kinases Flavonoids Glucose Transporter Type 1 biology Dose-Response Relationship Drug Glucose transporter Imidazoles Biological Transport General Medicine Fibroblasts Kinetics Endocrinology Glucose Pyrimidines chemistry Mechanism of action biology.protein Pyrazoles GLUT1 medicine.symptom |
| Popis: | Berberine, which has a long history of use in Chinese medicine, has recently been shown to have efficacy in the treatment of diabetes. While the hypoglycemic effect of berberine has been clearly documented in animal and cell line models, such as 3T3-L1 adipocytes and L6 myotube cells, the mechanism of action appears complex with data implicating activation of the insulin signaling pathway as well as activation of the exercise or AMP kinase-mediated pathway. There have been no reports of the acute affects of berberine on the transport activity of the insulin-insensitive glucose transporter, GLUT1. Therefore, we examined the acute effects of berberine on glucose uptake in L929 fibroblast cells, a cell line that express only GLUT1. Berberine activated glucose uptake reaching maximum stimulation of five fold at >40 μM. Significant activation (P |
| Databáze: | OpenAIRE |
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