IgM-mediated Warm Autoimmune Hemolytic Anemia: An Autopsy Report
| Autor: | Keiko Takashiro, Toshiyuki Obata, Takahiko Ito, Noriko Takahara, Kouhei Yoshimura, Natsuka Tojo, Kazuyo Yamamoto, Shigeo Hara, Kouhei Takesue, Naoko Yoshimatsu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Hemolytic anemia Case Report Autopsy 030204 cardiovascular system & hematology 03 medical and health sciences Fatal Outcome 0302 clinical medicine Internal Medicine medicine Humans Lupus Erythematosus Systemic autoimmune hemolytic anemia warm antibody Aged business.industry General Medicine medicine.disease Antibodies Anti-Idiotypic Complement system Impaired consciousness Agglutination (biology) Immunoglobulin M Immunology Autopsy report 030211 gastroenterology & hepatology Rituximab Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.1291-18 |
| Popis: | A 79-year-old man with Sjögren's syndrome and systemic lupus erythematosus developed acute impaired consciousness and hemolytic anemia. The patient's red blood cells agglutinated spontaneously at 25-37°C. The treatment of red blood cells with 2-mercaptoethanol resulted in the loss of spontaneous agglutination. A diagnosis of IgM-mediated warm autoimmune hemolytic anemia was made. The patient received steroid pulse and plasma exchange therapies. Rituximab was also administered. However, the patient died from multiple organ failure at six days from the symptom onset. The clinical progress of the patient and autopsy findings suggested that complement activation might have been associated with the pathology. |
| Databáze: | OpenAIRE |
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