Representation of distinct reward variables for self and other in primate lateral hypothalamus
| Autor: | Atsushi Noritake, Taihei Ninomiya, Masaki Isoda |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Value (ethics) Lateral hypothalamus Conditioning Classical Affect (psychology) self Reward biology.animal Animals Primate Social Behavior Prefrontal cortex Multidisciplinary biology macaque other Representation (systemics) Classical conditioning Information flow lateral hypothalamus Biological Sciences Hypothalamic Area Lateral Macaca Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1917156117 |
| Popis: | Significance Motivation is affected by rewards to both oneself and others. Which brain regions separately monitor self-rewards and other-rewards? It has been thought that higher-order, neocortical regions, such as the medial prefrontal cortex, monitor behavioral information in agent-selective manners. Here, we show that a subcortical region called the lateral hypothalamus (LH), an evolutionarily old structure in the vertebrate brain, also contains agent-specific reward information and further integrates it into a subjective reward value. This other-reward–dependent value signal is causally used for adaptive behavior, because deactivation of LH cells totally eliminates the motivational impact of other-rewards. Our findings indicate that the LH is an integral component of social brain networks and shapes socially motivated behavior via functional coordination with neocortical regions. The lateral hypothalamus (LH) has long been implicated in maintaining behavioral homeostasis essential for the survival of an individual. However, recent evidence suggests its more widespread roles in behavioral coordination, extending to the social domain. The neuronal and circuit mechanisms behind the LH processing of social information are unknown. Here, we show that the LH represents distinct reward variables for “self” and “other” and is causally involved in shaping socially motivated behavior. During a Pavlovian conditioning procedure incorporating ubiquitous social experiences where rewards to others affect one’s motivation, LH cells encoded the subjective value of self-rewards, as well as the likelihood of self- or other-rewards. The other-reward coding was not a general consequence of other’s existence, but a specific effect of other’s reward availability. Coherent activity with and top-down information flow from the medial prefrontal cortex, a hub of social brain networks, contributed to signal encoding in the LH. Furthermore, deactivation of LH cells eliminated the motivational impact of other-rewards. These results indicate that the LH constitutes a subcortical node in social brain networks and shapes one’s motivation by integrating cortically derived, agent-specific reward information. |
| Databáze: | OpenAIRE |
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