Assessment of hypercoagulability markers and lipid levels in postmenopausal women undergoing either oral or transdermal hormone replacement therapy
| Autor: | Túlio César Alvim, Ana Paula Fernandes, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho, George da Silva Teixeira, Marinez O. Sousa, Jarbas E. Cardoso, Daniela Amorim Melgaço Guimarães, Romerson Martins Franco, Hilton de Almeida Franco |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
genetic structures Hormone Replacement Therapy medicine.medical_treatment Administration Oral Blood lipids Administration Cutaneous Gastroenterology Internal medicine medicine Humans Thrombophilia Blood Coagulation Aged Transdermal Hemostasis Hematology Postmenopausal women business.industry Fibrinolysis Hormone replacement therapy (menopause) Plasma levels Middle Aged medicine.disease Lipids Thrombosis eye diseases Postmenopause Endocrinology Female sense organs Cardiology and Cardiovascular Medicine business Biomarkers Brazil |
| Zdroj: | Journal of Thrombosis and Thrombolysis. 27:135-140 |
| ISSN: | 1573-742X 0929-5305 |
| Popis: | Background This study investigated the effect of either oral or transdermal hormone replacement therapy (HRT) on haemostatic, fibrinolytic and lipid profiles in a group of Brazilian women 3 months after beginning treatment by comparing these results with those obtained immediately before HRT. Methods Plasma levels of TAT, DDi, F1+2, PC, PS, AT, PAI-1 and serum lipids were determined in blood samples collected from 24 women undergoing oral HRT and from 11 women undergoing transdermal HRT. Results Significant increases in DDi and F1+2 plasma levels were observed after 3 months of oral HRT, while PS levels decreased. After transdermal HRT, a significant decrease was observed only for AT levels. Conclusion After 3 months of oral HRT and in the absence of major genetic and acquired risk factors, women displayed a predisposition for activation of blood coagulation, and an increased activity of the fibrinolytic system. Oral HRT seemed to be more effective in predisposing haemostatic changes as compared to transdermal. |
| Databáze: | OpenAIRE |
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