Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses
| Autor: | R Eliashar, H Sohmer, Elidan J, J Y Sichel, M Plotnik |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Cochlear Diseases Administration Topical medicine.medical_treatment Sodium Chloride Audiology Ototoxicity Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases medicine Animals Evoked potential Saline Cochlea Antibacterial agent Vestibular system business.industry medicine.disease Anti-Bacterial Agents Rats Disease Models Animal Pharmaceutical Solutions medicine.anatomical_structure Vestibular Diseases Otorhinolaryngology Vestibule Evoked Potentials Auditory Middle ear sense organs Gentamicins Gerbillinae business |
| Zdroj: | American Journal of Otolaryngology. 21:192-195 |
| ISSN: | 0196-0709 |
| Popis: | Introduction The cochlear ototoxicity of several ear drops is well documented in the literature, but very few studies exist on the vestibular ototoxicity of these topical drugs. Goal of study To develop an animal model for the assessment of the vestibular ototoxicity of ear drops. Materials and methods Two animal groups, consisting of five fat sand rats (FSRs) each, underwent unilateral labyrinthectomy. Normal saline was topically applied into the middle ear cavity of rats in the first group for 7 days (control group). Rats in the second group were treated in the same way by topical gentamicin solution. Cochlear function was assessed by the recording of auditory evoked potential (ABPs) thresholds, and vestibular function was assessed by the recording of vestibular evoked potentials (VsEPs) to angular accelerations. Results In the control group, except for the amplitude of the first wave, there was no significant difference in the VsEPs recorded before and after topical application. In the gentamicin group, VsEPs could not be recorded after 7 days, and ABPs were recorded in one case only, with a threshold of 100 dB sound pressure level (SPL). Conclusion VsEPs seem to be a reliable measure for evaluating the vestibular ototoxicity of topical ear drops. |
| Databáze: | OpenAIRE |
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