Involvement of dopamine D1 and D2 receptors in the rat nucleus accumbens in immunostimulation
| Autor: | E. L. Al'perina, L. V. Devoino, M. M. Gevorgyan, M. A. Cheido |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Agonist medicine.medical_specialty Erythrocytes Quinpirole Rosette Formation medicine.drug_class Nucleus accumbens Nucleus Accumbens Dopamine receptor D1 Dopamine Internal medicine Dopamine receptor D2 medicine Animals Rats Wistar Receptor Analysis of Variance Sheep Receptors Dopamine D2 Chemistry Receptors Dopamine D1 General Neuroscience Rats Endocrinology Dopamine receptor Dopamine Agonists Immunization 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Endogenous agonist medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 37:147-151 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-007-0162-9 |
| Popis: | Analysis of the nature of changes in the immune response in operated Wistar rats showed that electrolytic lesioning of the nucleus accumbens, the site of the greatest density of dopamine D1 and D2 receptors, led to suppression of the immune response in animals immunized with sheep erythrocytes. Administration of SKF 38393 (20 mg/kg) and quinpirol (1 mg/kg), selective agonists of dopamine D1 and D2 receptors respectively, to sham-operated rats induced significant increases in immune responses. However, no immunostimulation was seen on administration of the selective dopamine D2 agonist quinpirol to animals with lesions to the nucleus accumbens as compared with controls. At the same time, treatment of animals with nucleus accumbens lesions using the dopamine D1 receptor agonist SKF 38393 had no effect on the immune response as compared with that in sham-operated animals given the D1 receptor agonist. These data provide evidence that dopamine D2 receptors in the nucleus accumbens have a role in the mechanisms of immunostimulation, though D2 receptors in other brain structures may also make some contribution to this process; D1 receptors in the nucleus accumbens make no significant contribution to controlling the immune response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink