Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement
| Autor: | Gutian Zhang, Jinlong Li, Lin Du, Wenting Cheng, Chuanjun Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Hyperthermia lcsh:Medical technology Cell Survival Infrared Rays Xanthones medicine.medical_treatment lcsh:Biotechnology Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Antineoplastic Agents Bioengineering Photodynamic therapy Applied Microbiology and Biotechnology Hsp90 inhibitor Mice chemistry.chemical_compound Heat shock protein lcsh:TP248.13-248.65 Tumor Microenvironment medicine Animals Photosensitizer HSP90 Heat-Shock Proteins Hypoxia Heat-Shock Proteins Mice Inbred BALB C Photosensitizing Agents Tumor hypoxia Chemistry Research Oxides Phototherapy Photothermal therapy medicine.disease Manganese Compounds lcsh:R855-855.5 Cancer research Nanoparticles Molecular Medicine Gambogic acid Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021) Journal of Nanobiotechnology |
| ISSN: | 1477-3155 |
| Popis: | BackgroundPhototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement.ResultsNear-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO2on the surface to form IGM nanoparticles. Both in vitro and in vivo studies demonstrated that IGM could catalyze overexpress of hydrogen peroxide to relive hypoxic tumor microenvironment. With near infrared irradiation, the ROS generation was significantly increase for PDT enhancement. In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. As a result, IGM could achieve better antitumor efficacy with enhanced PDT and PTT.ConclusionThis study develops a facile approach to co-deliver IR780 and GA with self-assembled albumin nanoparticles, which could relive hypoxia and suppress Hsp for clinical application of cancer phototherapy. |
| Databáze: | OpenAIRE |
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