Effect of proinflammatory cytokines (IL-6, TNF-alpha, IL-1beta) on hemodynamic performance during orthotopic liver transplantation
| Autor: | J Arranz, A Soriano, I Garcia, I García, M.T Concepción, J Navarro, A Arteaga, X Filella, P Bravo, M Barrera, S Escribano, A Jiménez, E Moneva, J Fernandez, A Varona, E Herrero, D Dominguez |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Pathology Cardiac output medicine.medical_treatment Hemodynamics Blood Pressure Liver transplantation Gastroenterology Proinflammatory cytokine Heart Rate Internal medicine medicine.artery Monitoring Intraoperative medicine Humans Cardiac Output Transplantation business.industry Interleukin-6 Tumor Necrosis Factor-alpha Liver Transplantation medicine.anatomical_structure Pulmonary artery Vascular resistance Cytokines Surgery Vascular Resistance Hepatectomy business Biomarkers Interleukin-1 |
| Zdroj: | Transplantation proceedings. 35(5) |
| ISSN: | 0041-1345 |
| Popis: | Background Proinflammatory cytokines (IL-6, IL-1β, TNF-α) released during liver transplantation may affect hemodynamic stability. The aim of the present study was to analyze the association between IL-6, TNF-α, and IL-1β and systemic vascular resistance during the phases of liver transplantation. Material and methods The proinflammatory cytokines IL-6, IL-1β, and TNF-α were analyzed in the blood of 20 consecutive patients who underwent transplantation. Blood samples were drawn from the pulmonary artery at serial times during surgery. Hemodynamic parameters were determined using a cardiac output monitor. Correlations between parameters were analyzed using the Spearman's rho and Kendall's tau-b methods. Results Both in the vena cava and the pulmonary artery, significant association was observed between basal values of IL-6 during hepatectomy and systemic vascular resistance during the phases of liver transplantation: hepatectomy phase (r = .76, P = .02), anhepatic phase (r = .78, P = .03) and reperfusion phase (r = .87, P = .005). Conclusions Basal values of IL-6 may be considered a prognostic factor for hemodynamic performance during the phases of liver transplantation. |
| Databáze: | OpenAIRE |
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