New Curcumin-Loaded Chitosan Nanocapsules: In Vivo Evaluation
| Autor: | Maria Isabel Briceño, Alicia Torres, Edgar Marin, Catherina Caballero-George |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Curcumin Pharmaceutical Science 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Nanocapsules Analytical Chemistry Chitosan Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Drug Discovery Animals Curcuma Solubility biology Organic Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Bioavailability Drug Liberation Complementary and alternative medicine chemistry Molecular Medicine 0210 nano-technology Drug carrier Nuclear chemistry |
| Zdroj: | Planta Medica. 83:877-883 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0043-104633 |
| Popis: | The medicinal applications of curcumin, the major component of Curcuma longa, are limited by its poor solubility and low oral bioavailability. In order to overcome this limitation, a method to produce nanocapsules of chitosan loaded with curcumin was developed. Three different molecular weight and deacetylation degree chitosan polymers were used in the formulation in order to prepare curcumin-loaded nanocapsules (mass ratio 1 : 1.4). The best results were achieved using chitosan-Bi with a molecular weight of 710 000 Da. A bimodal distribution was observed in samples; moreover, chitosan-Bi produced the lowest particle size (197 nm). The entrapment efficacy of all chitosan nanocapsules produced reached values between 75 and 92 %. Their rate of drug release at different pH levels (2.0 and 7.4) showed a fast onset of curcumin release. Swiss mice were used to determine oral and total bioavailability of the new curcumin-loaded nanocapsules. Remarkably, the bioavailability of curcumin nanoformulated increased 9-fold compared with no formulated curcumin. These nanocapsules have the ability to cross the blood-brain barrier, and its production is an easy to scale-up procedure using nontoxic materials. |
| Databáze: | OpenAIRE |
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