PPARα contributes to colonic protection in mice with DSS-induced colitis
| Autor: | Yasu-Taka Azuma, Yukiko Matsuo, Kazuhiro Nishiyama, Mitsuru Kuwamura, Hidemitsu Nakajima, Tadayoshi Takeuchi, Ai Morioka |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Colon medicine.medical_treatment Immunology Inflammation Biology Inflammatory bowel disease Mice Internal medicine medicine Animals Immunology and Allergy PPAR alpha Colitis Receptor Acute colitis Pharmacology Gastrointestinal tract Dextran Sulfate medicine.disease digestive system diseases Pyrimidines Endocrinology Cytokine Gene Expression Regulation medicine.symptom Homeostasis |
| Zdroj: | International Immunopharmacology. 10:1261-1267 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2010.07.007 |
| Popis: | Inflammatory bowel disease (IBD) is characterized by repeated chronic inflammation of the gastrointestinal tract. We have used the complementary model of colonic inflammation to examine the roles of peroxisome proliferator-activated receptor α (PPARα) in colonic inflammation and thus its possible role in IBD. We characterized an innate immune-mediated model of colitis induced by dextran sulfate sodium (DSS). Mice with DSS-induced colitis were injected with Wy-14643 (2 mg/kg) as a PPARα agonist every day from day 0 to day 5. We show that mice given Wy-14643 were less susceptible to experimental acute colitis induced by DSS, and this decreased susceptibility was correlated with decreased production of IFNγ, IL-1β, IL-6, and TNF-α. Our findings suggest that PPARα has a role in controlling colonic inflammation and mucosal tissue homeostasis. |
| Databáze: | OpenAIRE |
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