Sugar Amino Acid Containing Somatostatin Analogues that Induce Apoptosis in Both Drug-Sensitive and Multidrug-Resistant Tumor Cells
| Autor: | Richard Schwab, Horst Kessler, and Aniko Venetianer, Sibylle A. W. Gruner, Gyorgy Keri |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Drug
media_common.quotation_subject medicine.medical_treatment Cancer therapy Antineoplastic Agents Apoptosis Tumor cells Biochemistry Structure-Activity Relationship Hormone Antagonists Tumor Cells Cultured medicine Animals Amino Acids Physical and Theoretical Chemistry media_common Chemotherapy Chemistry Organic Chemistry Sugar Acids Rats Multiple drug resistance Somatostatin Drug Resistance Neoplasm Cancer research Sugar amino acid Drug Screening Assays Antitumor Algorithms |
| Zdroj: | Organic Letters. 3:3723-3725 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0166698 |
| Popis: | [carbohydrate structure--see text] Resistance to chemotherapy has become a major problem in cancer therapy. The new sugar amino acid (SAA) containing somatostatin analogues presented possess antiproliferative and apoptotic activity against both multidrug-resistant and drug-sensitive hepatoma carcinoma cells. Synthesis, design, and biological evaluation of the cyclic analogues and of the furanoid SAA used will be discussed. Four analogues have IC(50) values in the low microM range, making them promising leads for chemotherapeutic drugs against multidrug-resistant carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|