Peripheral blood complete remission after splenic irradiation in mantle-cell lymphoma with 11q22-23 deletion and ATM inactivation

Autor: Pierfrancesco Franco, Umberto Ricardi, Marco Galliano, Andrea Riccardo Filippi
Rok vydání: 2006
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Pathology
medicine.medical_specialty
lcsh:R895-920
Short Report
Lymphoproliferative disorders
Abscopal effect
Spleen
Cell Cycle Proteins
Ataxia Telangiectasia Mutated Proteins
Lymphoma
Mantle-Cell
Radiotherapy
Spleen irradiation
Mantle cell lymphoma
Protein Serine-Threonine Kinases
lcsh:RC254-282
medicine
Humans
Radiology
Nuclear Medicine and imaging
Radiosensitivity
Splenic marginal zone lymphoma
B-Lymphocytes
Radiotherapy
medicine.diagnostic_test
business.industry
Chromosomes
Human
Pair 11
Tumor Suppressor Proteins
Remission Induction
Spleen irradiation
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Prognosis
Lymphoproliferative Disorders
Lymphoma
DNA-Binding Proteins
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
Phenotype
Oncology
Chromosomal region
Chromosome Deletion
business
Biomarkers
Fluorescence in situ hybridization
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 1, Iss 1, p 35 (2006)
ISSN: 1748-717X
Popis: Mantle Cell Lymphoma (MCL) is a well-known histological and clinical subtype of B-cell non-Hodgkin's Lymphomas. It is usually characterized by an aggressive disease course, presenting with advanced stage disease at diagnosis and with low response rates to therapy. However few cases of indolent course MCL have been described. We herein report a case of MCL with splenomegaly and peripheral blood involvement as main clinical features. The patient underwent moderate dose splenic radiation therapy and achieved spleen downsizing and peripheral blood complete remission. Splenic irradiation has been extensively used in the past as palliative treatment in several lymphoproliferative disorders and a systemic effect and sometimes peripheral blood complete remissions have been observed. Mainly advocated mechanisms responsible for this phenomenon are considered direct radiation-induced apoptotic cell death, immune modulation via proportional changes of lymphocyte subsets due to known differences in intrinsic radiosensitivity and a radiation-induced cytokine release. The peculiar intrinsic radiosensitivity pattern of lymphoid cells could probably be explained by well-defined individual genetic and molecular features. In this context, among NHLs, MCL subtype has the highest rate of ATM (Ataxia Teleangiectasia Mutated) inactivation. While the ATM gene is thought to play a key-role in detecting radiation-induced DNA damage (expecially Double Strand Breaks), recent in vitro data support the hypothesis that ATM loss may actually contribute to the radiosensitivity of MCL cells. ATM status was retrospectively investigated in our patient, with the tool of Fluorescence In Situ Hybridization, showing a complete inactivation of a single ATM allele secondary to the deletion of chromosomal region 11q22-23. The presence of this kind of cytogenetic aberration may be regarded in the future as a potential predictive marker of radiation response.
Databáze: OpenAIRE
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