Postprandial glucose-lowering effect of cagaita (Eugenia dysenterica DC) fruit juice in dysglycemic subjects with metabolic syndrome: An exploratory study
| Autor: | J. Alberto Martinez-Blazquez, Renata Luise de Araujo, Francisco A. Tomás-Barberán, Maria Inés Genovese, Rosa Ferreira dos Santos |
|---|---|
| Přispěvatelé: | Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) |
| Rok vydání: | 2020 |
| Předmět: |
Bioavailability
030309 nutrition & dietetics medicine.medical_treatment Urine Gastric Inhibitory Polypeptide Eugenia Urolithins Postprandial hyperglycemia 03 medical and health sciences 0404 agricultural biotechnology Ellagitannins Medicine Humans Food science Glycemic Metabolic Syndrome 0303 health sciences business.industry Insulin Cagaita Area under the curve 04 agricultural and veterinary sciences medicine.disease Postprandial Period 040401 food science Fruit and Vegetable Juices Postprandial SUCOS DE FRUTAS Blood sugar regulation Metabolic syndrome business Food Science |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-7145 |
| Popis: | Cagaita (Eugenia dysenterica DC) is an ellagitannin-containing Myrtaceae fruit from Cerrado biome. This fruit seems to be a promising candidate for an adjuvant in glucose regulation in healthy subjects. However, it is not known whether cagaita juice would have the same effect on dysglycemic subjects with metabolic syndrome (MetS). Therefore, the present work aimed to evaluate the effect of cagaita fruit juice on postprandial glycemia in dysglycemic subjects with MetS, and whether cagaita ellagitannins could be metabolized to urolithins. To evaluate glycemic effects, two different meals were consumed by volunteers (n = 12) with a 1-week interval among them. The first one consisted of white bread (50 g) plus water (300 mL) as a control; the second one, white bread (50 g) plus clarified cagaita juice (300 mL). Bioavailability was assessed in 24 h urine, after the consumption of a single amount of 300 mL of cagaita juice by healthy (n = 16) and MetS subjects (n = 7). The results showed that dysglycemic subjects with MetS presented a 53% reduction of incremental area under the curve (iAUC) of glucose, 38% reduction of insulin, 78% reduction of GIP (glucose-dependent insulinotropic polypeptide), and 58% reduction of C-peptide (p < 0.05), after the consumption of cagaita juice along with bread, in comparison to control water. However, both GLP-1 (glucagon-like peptide-1) and glucagon were not affected by cagaita juice ingestion. Concerning bioavailability, it was observed, for the first time, the metabolization of cagaita ellagitannins to urolithins by healthy and dysglycemic individuals with MetS, with a prevalence of metabotype B in both groups (44% and 42%, respectively), followed by metabotype A (37% and 29%, respectively), and metabotype 0 (19% and 29%, respectively). We thank all volunteers, nursing staff, the support of the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) – Brasil (protocol number: 8881.187903/2018-01) |
| Databáze: | OpenAIRE |
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