Tolfenamic acid rapid release versus sumatriptan in the acute treatment of migraine: comparable effect in a double-blind, randomized, controlled, parallel-group study
| Autor: | Heikki Vapaatalo, Jukka Turkka, P. Kangasniemi, Vilho V. Myllylä, Hannele Havanka, Ole Eskerod, Lauri Herrala, Ilkka Rautakorpi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Randomization Prostaglandin Antagonists medicine.medical_treatment Migraine Disorders Placebo law.invention 03 medical and health sciences 0302 clinical medicine Tolfenamic acid Randomized controlled trial Double-Blind Method law medicine Humans ortho-Aminobenzoates 030212 general & internal medicine Adverse effect Dosage Forms Chemotherapy business.industry Sumatriptan Middle Aged medicine.disease 3. Good health Serotonin Receptor Agonists Neurology Migraine Anesthesia Acute Disease Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Headache. 38(3) |
| ISSN: | 0017-8748 |
| Popis: | The efficacy and safety of tolfenamic acid and oral sumatriptan in the acute treatment of migraine was studied at five neurological centers in Finland. One hundred forty-one patients experiencing 289 migraine attacks, fulfilling the diagnostic criteria for migraine with or without aura as defined by the International Headache Society, were randomized. For first attacks, 77% of patients receiving tolfenamic acid experienced a reduction of the initial severe or moderate headache to mild or no headache after 2 hours, as compared to 79% in the sumatriptan group and 29% in the placebo group. No significant difference was found between active treatments (P=0.85, 95% Cl [−22%, 18%]), however, both active treatments were significantly better than placebo; P=0.001, 95% Cl (26%, 69%) for tolfenamic acid and P=0.001, 95% Cl (28%, 71%) for sumatriptan. For second attacks, results were similar with 70% of patients receiving tolfenamic acid experiencing relief, as compared to 64% in the sumatriptan group and 39% in the placebo group. No significant differences were observed in accompanying symptoms. Both drugs were well tolerated with the frequency of adverse events; 30% for tolfenamic acid and 41% for sumatriptan, a nonsignificant difference. In this study, tolfenamic acid and oral sumatriptan are comparably effective in the acute treatment of migraine. When comparably effective, factors like individual effect, tolerance, and cost of treatment should be considered when prescribing migraine medication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text