Direct Participation of Starburst Amacrine Cells in Spontaneous Rhythmic Activities in the Developing Mammalian Retina
| Autor: | Zhou Zj |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Retinal Ganglion Cells
Periodicity Patch-Clamp Techniques genetic structures Rhythmic excitation Interneuron Action Potentials Giant retinal ganglion cells Article Retina Amacrine cell medicine Animals Ganglion cell layer Fluorescent Dyes Chemistry General Neuroscience Intrinsically photosensitive retinal ganglion cells Isoquinolines Retinal waves medicine.anatomical_structure Cholinergic Fibers Synapses Rabbits sense organs Neuroscience |
| Zdroj: | The Journal of Neuroscience. 18:4155-4165 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.18-11-04155.1998 |
| Popis: | Spontaneous, rhythmic waves of excitation in the developing mammalian retina play a critical role in the formation of precise neuronal connectivity in the visual system. However, it is not known what circuits in the retina are responsible for the production of these waves. Using patch-clamp recordings in the whole-mount neonatal rabbit retina, this study reports that the displaced starburst amacrine cell, a unique cholinergic interneuron in the ganglion cell layer of the retina, undergoes rhythmic bursts of membrane depolarization with a frequency and duration similar to those of spontaneous retinal waves. Simultaneous patch-clamp recordings from pairs of neighboring starburst and ganglion cells show that the rhythmic activity in starburst cells is closely correlated with that in ganglion cells, and that the excitation in both cell types is most likely driven by synaptic input. However, in contrast to ganglion cells, displaced starburst cells usually do not generate spontaneous somatic action potentials. Instead, they seem to use subthreshold potentials (at least at the soma) to mediate the rhythmic excitation. The results suggest that acetylcholine is likely released rhythmically in the developing retina. Thus, starburst amacrine cells form the first identified network of retinal interneurons that directly participate in spontaneous rhythmic activities in the developing retina. |
| Databáze: | OpenAIRE |
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