Value of prostate specific antigen in predicting the existence of bone metastasis in scintigraphy
| Autor: | Ernani Luis Rhoden, Olavo Machado Torres, Carlos Ary Vargas Souto, Rafael R. Lemos, Gabriel Z. Ramos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Urology lcsh:RC870-923 Scintigraphy prostatic neoplasms neoplasm metastasis Antigen Prostate medicine prostate-specific antigen skeleton neoplasm staging prostate medicine.diagnostic_test business.industry Bone metastasis lcsh:Diseases of the genitourinary system. Urology medicine.disease Predictive value Prostate-specific antigen medicine.anatomical_structure Bone scintigraphy Neoplasm staging business |
| Zdroj: | International braz j urol, Volume: 29, Issue: 2, Pages: 121-126, Published: APR 2003 International braz j urol v.29 n.2 2003 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 29, Iss 2, Pp 121-126 (2003) |
| Popis: | Objective: Evaluate the ability of serum concentration of prostate specific antigen (PSA) between 2cutting points to predict the existence of bone metastasis confirmed by bone scintigraphy in manwith prostate cancer.Materials and Methods: Two hundred and fourteen consecutive patients with prostate cancerwere evaluated during the present study in the period from 1998 to 2001. From all patients, PSAserum concentrations and bone scintigraphy were obtained. For the study, 2 cutting points of PSA(10 and 20 ng/mL) were adopted to predict the existence of bone metastasis.Results: From the 214 patients, 35 (16.3%) presented positive scintigraphic examinationsfor the presence of bone metastasis. No patient presented bone metastasis in scintigraphy if havingPSA < 10 ng/mL, and in only 1 patient (0.46%) with bone metastasis PSA concentration was < 20ng/mL. Therefore, when the cutting point adopted for PSA serum concentration was 10 ng/mL, anegative predictive value for bone metastasis was 100% with sensitivity rates of 100%. Nevertheless,the positive predictive value and the specificity of the method were, respectively, 24.5% and 39.7%.When the cutting point of PSA serum concentration was 20 ng/mL, an increment was observed inrates of positive predictive value and specificity (41.5% and 73.2%), respectively, without substantialchanges in negative predictive value (99.2%) and sensitivity (97.1%) of the method.Conclusions: Data of present study allow for the conclusion that PSA serum concentrationover 20 ng/mL was a more accurate cutting point than PSA serum concentration over 10 ng/mL topredict the presence of bone metastasis in scintigraphy.Key words: prostate; prostatic neoplasms; prostate-specific antigen; neoplasm staging; neoplasmmetastasis; skeletonInt Braz J Urol. 2003; 29: 121-6 |
| Databáze: | OpenAIRE |
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