Cell therapy for spinal cord injury using induced pluripotent stem cells

Autor: Narihito Nagoshi, Osahiko Tsuji, Hideyuki Okano, Masaya Nakamura
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
OPCs
oligodendrocyte progenitor cells
GCV
ganciclovir
Review Article
HSVtk
herpes simplex virus type I thymidine kinase
Regenerative medicine
NPCs
neural precursor cells
drNPCs
directly reprogrammed neural precursor cells
Cell therapy
0302 clinical medicine
GSI
γ-secretase inhibitor
CST
corticospinal tract
Induced pluripotent stem cell
Spinal cord injury
lcsh:R5-920
lcsh:Cytology
iPSCs
induced pluripotent stem cells
ASIA
American Spinal Injury Association
CiRA
the Center for iPS Cell Research and Application
Clinical application
Induced pluripotent stem cells
medicine.anatomical_structure
lcsh:Medicine (General)
SLA
swine leukocyte antigen
Central nervous system
Neural precursor cells
Biomedical Engineering
MLR
mixed lymphocyte reaction
Biomaterials
SCI
spinal cord injury
03 medical and health sciences
C-ABC
chondroitinase ABC
Precursor cell
medicine
lcsh:QH573-671
PBMCs
peripheral blood mononuclear cells
HLA
human leukocyte antigen
business.industry
ESCs
embryonic stem cells
medicine.disease
CSPGs
chondroitin sulfate proteoglycans
Transplantation
030104 developmental biology
HMGB1
high mobility group box-1
business
NHPs
nonhuman primates
Stem cell biology
Neuroscience
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Regenerative Therapy, Vol 11, Iss, Pp 75-80 (2019)
Regenerative Therapy
ISSN: 2352-3204
Popis: For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.
Highlights • Transplantation of iPSC-derived neural precursor cells (NPCs) shows beneficial effects for spinal cord injury (SCI). • Because unsafe iPSC-NPC lines can form tumors after grafting, provisions to attenuate this risk are substantially important. • Clinical application for SCI patients using iPSCs will be conducted in the near future.
Databáze: OpenAIRE
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