Univariate and multivariate models for the prediction of life-threatening complications in 586 cases of deep neck space infections: retrospective multi-institutional study
| Autor: | Jan Mejzlík, T. Hoskova, Milos Kotulek, Petr Matoušek, Luboš Tuček, P Mittu, A Pazs, Petr Celakovsky, A. Vrbacky, Lucia Staníková, Viktor Chrobok |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Severity of Illness Index Young Adult 03 medical and health sciences 0302 clinical medicine Severity of illness Humans Medicine 030223 otorhinolaryngology Fasciitis Survival analysis Retropharyngeal space Aged Retrospective Studies Aged 80 and over Univariate analysis business.industry Incidence (epidemiology) Retrospective cohort study Bacterial Infections General Medicine Middle Aged Models Theoretical medicine.disease Survival Analysis Surgery medicine.anatomical_structure Otorhinolaryngology Etiology Female business Neck 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Laryngology & Otology. 131:779-784 |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Objective:To identify deep neck infection factors related to life-threatening complications.Methods:This retrospective multi-institutional study comprised 586 patients treated for deep neck infections between 2002 and 2012. The statistical significance of variables associated with life-threatening complications of deep neck infections was assessed.Results:During treatment, life-threatening complications occurred in 60 out of 586 cases. On univariate analysis, life-threatening complications were linked to: dyspnoea, neck movement disturbance and dysphonia (all p < 0.001); and parapharyngeal, anterior visceral or pretracheal deep neck involvement (all p < 0.002). Aetiology was significantly linked to tonsils (p < 0.001). Regarding infection type, fasciitis was a significant factor (p < 0.001). Candida albicans was a significant bacterial culture (p < 0.001). A multivariate step-wise model disclosed fewer significant variables: retropharyngeal space (p = 0.005) and major blood vessels area (p = 0.006) involvement, and bacterial culture C albicans (p < 0.001).Conclusion:It can be predicted that patients with deep neck infections, with neck movement disturbances, dysphonia, dyspnoea and swelling of the external neck, accompanied by severe pain, and inflammatory changes in the retropharyngeal space and large vessel areas, with culture-confirmed infection of C albicans, are likely to develop life-threatening complications. |
| Databáze: | OpenAIRE |
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