Progestasert: A Uterine Therapeutic System for Long-term Contraception: I. Philosophy and Clinical Efficacy
| Autor: | Virgil A. Place, John D. Bashaw, Bruce B. Pharriss, Ross R. Erickson, Alejandro Zaffaroni, Seymour Hoff |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Time Factors Biopsy medicine.medical_treatment Endometrium medicine Humans Clinical efficacy Uterine lumen Progesterone Vaginal Smears Gynecology Progestogen business.industry Obstetrics Obstetrics and Gynecology Parity Pregnancy rate Contraception medicine.anatomical_structure Reproductive Medicine Family planning Delayed-Action Preparations Total removal Female Delivery system business Contraceptives Oral Intrauterine Devices |
| Zdroj: | Fertility and Sterility. 25:915-921 |
| ISSN: | 0015-0282 |
| Popis: | An intrauterine steroid delivery system the Progestasert system, is described and studies of its clinical efficacy are reported. The Progestasert system combines the advantageous features of IUDs and oral minidose progestogen preparations. An internal device continuously delivers progesterone for 1 year to the uterine lumen and endometrium. A T-shaped Progestasert which releases 65 mcg/day has been selected for wide scale clinical use. A total of 3121 parous women used Progestasert systems for 25,389 woman-months. The pregnancy rate was 1%, the expulsion rate 2.8%, and the total removal rate was 13%. The total continuation rate of the Progestasert system of 83.2% compares favorable with that of the Tatum-T-shaped IUD of 68.7%. These initial results aft er 1 year of use are most encouraging and suggest that the goals originally set for a contraceptive approach using intrauterine progester one are well within reach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|