Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: A population-based cross-sectional study
| Autor: | Young Bok Lee, Hyun Jeong Park, Miri Kim, Kwang Hyun Choi, Se Won Hwang, Jung Min Bae |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Alopecia Areata Vitiligo Dermatology Disease Skin Diseases Inflammatory bowel disease Dermatitis Atopic Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Sex Factors 0302 clinical medicine Crohn Disease Psoriasis Republic of Korea medicine Humans Child Aged Aged 80 and over Crohn's disease integumentary system business.industry Age Factors Atopic dermatitis Middle Aged Alopecia areata medicine.disease Ulcerative colitis digestive system diseases Cross-Sectional Studies Case-Control Studies Rosacea Immunology Colitis Ulcerative Female 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of the American Academy of Dermatology. 76:40-48 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2016.08.022 |
| Popis: | Background Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract attributed to aberrant activity of the immune system. Increasing evidence suggests that patients with IBD are at an increased risk of inflammatory skin diseases (ISDs). Objective We sought to clarify the association between IBD and ISDs using a nationwide health claims database maintained in Korea. Methods We interrogated Korean health claim database data from 2009 to 2013. We enrolled all patients with IBD, and age- and sex-matched control subjects, and evaluated the risks of ISDs, including psoriasis, rosacea, and atopic dermatitis, and the risks of autoimmune skin diseases, including vitiligo and alopecia areata. We used multivariable logistic regression to this end. Results ISDs including rosacea, psoriasis, and atopic dermatitis were significantly associated with IBD, whereas the associations between IBD and autoimmune skin diseases including vitiligo and alopecia areata were less marked or nonexistent. Ulcerative colitis and Crohn's disease were both associated with ISDs. Limitations We were unable to distinguish phenotypes and severities of skin diseases. Conclusion IBD was significantly associated with ISDs, but less so or not at all with autoimmune skin diseases. |
| Databáze: | OpenAIRE |
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