Haloperidol-induced extrapyramidal reaction: lack of protective effect by vitamin E
| Autor: | Bangalore N. Gangadhar, V. Savithasri Eranti, N. Janakiramaiah |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Pharmacology medicine.disease_cause Antioxidants law.invention Randomized controlled trial Extrapyramidal symptoms Basal Ganglia Diseases Double-Blind Method law Oral administration Internal medicine Haloperidol Medicine Humans Vitamin E Prospective Studies Psychiatric Status Rating Scales business.industry Parkinsonism medicine.disease Endocrinology medicine.symptom business Oxidative stress medicine.drug Antipsychotic Agents |
| Zdroj: | Psychopharmacology. 140(4) |
| ISSN: | 0033-3158 |
| Popis: | Haloperidol treatment has been shown to produce oxidative stress in patients with acute psychosis. Oxidative stress has also been implicated in the extrapyramidal symptoms (EPS) produced by haloperidol. Supporting the oxidative stress hypothesis, vitamin E (antioxidant) has demonstrated therapeutic efficacy in idiopathic parkinsonism. The prophylactic efficacy of vitamin E (antioxidant) on haloperidol-induced EPS was examined in a randomized controlled trial. The sample consisted of 24 acute psychotic patients hospitalized for a 2-week trial. All patients received oral haloperidol 10 mg/day. The sample was equally randomized to receive either haloperidol alone or haloperidol + vitamin E (3200 IU/day). EPS was rated at recruitment, both live and with video records, and on days 3, 7, 10 and 14. Psychopathology was rated at recruitment and weekly thereafter. Vitamin E had no prophylactic effect on drug-induced EPS, though it did not interfere with the therapeutic efficacy of haloperidol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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