| Popis: |
The implication of minor histocompatibility antigens, such as Fya, in renal allograft rejection has been established, however the specificity of these antigens is still unknown. Acute rejection of an allograft amongst African American renal recipients has shown similar rates despite varying Duffy blood groups, however delayed graft function has shown a strong association with decreased allograft survival. African Americans are at greater risk of end-stage renal disease (ESRD) than non-African Americans and make up at least one third of ESRD patients in the USA. They also have a 30% to 40% decreased kidney- graft survival after transplantation compared with white patients. Although there is evidence of an immunologic role for Anti-Fya in graft survival, acute renal allograft rejection is not a current concern for allocation and matching of donor renal allografts. Non–major histocompatibility antigen immunity, regarding the Duffy system, is associated with chronic rather than acute graft loss. In the patient presented, their current renal allograft is reported to be functionally stable since transplantation. |
