Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment
| Autor: | Alfonso Cabrera Lagunes, Adriana Díaz-Anzaldúa, Gustavo Rojas Andrade, Vanessa-Giselle Peschard, Adriana Arias Caballero, César Enrique Gaspar-Barba, Arlette Yunes Jimenez, Francisco Rafael De la Peña Olvera, Carlos Sabas Cruz Fuentes, Miriam Feria-Aranda, Liz Sosa Mora, Armando Pérez Molina, Diana Guizar Sanchez, Lino Palacios-Cruz |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Adolescent Genotype CLOCK Proteins Medical and Health Sciences Polymorphism Single Nucleotide Clinical Research Genetics Humans Genetic Testing Polymorphism Biological Psychiatry Pediatric Psychiatry Circadian rhythm Psychology and Cognitive Sciences Neurosciences Single Nucleotide Attention Deficit Hyperactivity Disorder (ADHD) Attention deficit disorder with hyperactivity Single nucleotide polymorphism Thyroxine Psychiatry and Mental health Mental Health Good Health and Well Being Risk factors Attention Deficit Disorder with Hyperactivity Triiodothyronine Female |
| Zdroj: | Psychiatry Research. 317:114835 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2022.114835 |
| Popis: | This study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical and biological aspects previously associated with ADHD. 347 Mexican adolescents were assessed for mental disorders, metabolic disruption and related conditions, circadian preference, as well as genotyping for the CLOCK. We found a significant association between ADHD and the AA and AG genotypes of rs1801260. Also, we identified in the ADHD group that the total Triiodothyronine and total Thyroxine values were respectively 10ng/dl units and 0.58ug/dl units lower in females than in males. Previously reported common variations of the CLOCK gene have been associated with ADHD like the Rs1801260 polymorphism hereby we could consider it as risk factor, but genetic, biochemical and clinical studies in the Mexican population are entailed. |
| Databáze: | OpenAIRE |
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