Interactive effects of serotonin and acetylcholine on neurite elongation
| Autor: | John A. Connor, D. P. McCobb, S. B. Kater, Christopher S. Cohan |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Serotonin
Neurite Snails chemistry.chemical_compound medicine Animals Growth cone Neurotransmitter Cells Cultured Benzofurans Fluorescent Dyes Neurons Helisoma biology General Neuroscience biology.organism_classification Acetylcholine Axons Kinetics Spectrometry Fluorescence medicine.anatomical_structure chemistry Biophysics Excitatory postsynaptic potential Calcium Ganglia Neuron Fura-2 Neuroscience medicine.drug |
| Zdroj: | Neuron. 1:377-385 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/0896-6273(88)90187-0 |
| Popis: | Serotonin (5-HT) inhibits elongation of neurites of specific identified neurons. Here we report a novel, growth-enabling action of another neurotransmitter, acetylcholine (ACh). When applied simultaneously with serotonin, ACh prevents the inhibition of Helisoma neuron B19 neurite elongation that would occur in response to application of 5-HT alone. We also report that ACh prevents the rise in growth cone Ca2+ that would occur in response to application of 5-HT alone and that ACh blocks the electrical excitatory effect of 5-HT on neuron B19. These results support the hypothesis that growth cone motility and neurite elongation can be regulated by voltage-gated Ca2+ fluxes and suggest that the dynamics of neurite morphology may be complexly regulated by an array of neurotransmitters, as is functional electrical activity. |
| Databáze: | OpenAIRE |
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