The role of the regional lymph nodes in the augmentation of humoral immunity by Freund's complete adjuvant
| Autor: | J.C. Pierce, J.P. Neifeld, S.H. Ohanian |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Pathology
medicine.medical_specialty Erythrocytes medicine.medical_treatment Immunology Freund's Adjuvant Injection site Forelimb medicine Immunology and Allergy Animals Lymph node Saline Sheep business.industry General Medicine Hemagglutination Tests Hemagglutinin Complete adjuvant Rats medicine.anatomical_structure Humoral immunity Antibody Formation Female Lymph Lymph Nodes business |
| Zdroj: | International archives of allergy and applied immunology. 43(5) |
| ISSN: | 0020-5915 |
| Popis: | To evaluate the site of action of Freund’s complete adjuvant (FCA), adult rats were injected in a front footpad with sheep red blood cells in saline or FCA, followed by excision of the injected forelimb and the draining lymph nodes at varying intervals. When excisions were performed within 12 h, the hemagglutinin (HA) response, as measured 21–22 days after injection, was ablated in two thirds of the animals in both groups. When excisions were performed within 1–4 days, the HA responses were significantly reduced in both groups in comparison with their respective controls. Removal of only the injection site during the initial 8 h prevented the augmentation of the HA response by FCA. It was concluded that the augmentation of humoral immunity by FCA may be divided into three phases, the depot phase, the regional lymph node phase, and the phase of systemic dissemination. |
| Databáze: | OpenAIRE |
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