Response of biochemical markers of bone turnover to oral glucose load in diseases that affect bone metabolism
| Autor: | Konstantinos Tomos, Pantelis Zebekakis, Xanthippi Tsekmekidou, Maria P. Yavropoulou, Anna Gotzamani-Psarrakou, Michael Karamouzis, John G. Yovos, Olympia Anastasiou, Elenis Chassapopoulou, Panagiota Chalkia |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteocalcin Biology Bone tissue Hyperthyroidism Bone resorption Bone and Bones Collagen Type I Bone remodeling Endocrinology N-terminal telopeptide Hypothyroidism Internal medicine medicine Homeostasis Humans Glucose tolerance test Bone Development medicine.diagnostic_test beta-Thalassemia General Medicine Glucose Tolerance Test Middle Aged Bone Diseases Metabolic Postprandial medicine.anatomical_structure Glucose biology.protein Female Type I collagen Biomarkers Procollagen |
| Zdroj: | European journal of endocrinology. 164(6) |
| ISSN: | 1479-683X |
| Popis: | ObjectivePostprandial suppression of bone resorption is considered one of the main contributors in the circadian rhythm of bone turnover markers. The aim of this study was to investigate this physiological response of bone tissue in diseases that affect bone metabolism.Patients and methodsIn this study, 118 patients (45 hypothyroid, 40 hyperthyroid, and 33 β-thalassemic patients) and 78 healthy individuals matched for age and body mass index were included. An oral glucose test (75 g glucose) was performed after overnight fasting. Serum levels of procollagen type-I N-terminal propeptide (P1NP), β-C-terminal telopeptide of type I collagen (β-CTX), and osteocalcin were assayed at 0, 60, and 120 min.ResultsBaseline values of bone turnover markers were significantly elevated in hyperthyroid and β-thalassemic patients but not in hypothyroid patients compared with the control group. After oral glucose, the levels of β-CTX but not P1NP or osteocalcin were significantly suppressed in all groups (mean change from baseline is 46.9% for β-CTX, 7.9% for P1NP, and 8% for osteocalcin). The percentage change from baseline for β-CTX was significantly augmented in hypothyroidism (52 vs 42%, P=0.009).ConclusionThe preservation or even augmentation of postprandial suppression of bone resorption in diseases that affect bone metabolism through distinct pathogenetic mechanisms suggests the importance of this physiological response to nutrients for the general homeostasis and functional integrity of the skeleton. |
| Databáze: | OpenAIRE |
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