Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1

Autor: Jian‐Wei Su, Pei Yang, Mei‐Mei Xing, Bao Chen, Xia‐Hong Xie, Jian‐Hua Ding, Ming Lu, Yang Liu, Yue‐Wei Guo, Gang Hu
Rok vydání: 2022
Předmět:
Zdroj: CNS Neuroscience & Therapeutics. 29:893-906
ISSN: 1755-5949
1755-5930
DOI: 10.1111/cns.14025
Popis: To screen coral-derived compounds with neuroprotective activity and clarify the potential mechanism of lead compounds.The lead compounds with neuroprotective effects were screened by HThree compounds (No. 63, 68, and 74), derived from marine corals, could markedly alleviate the cell damage and notably reverse the loss of worm dopaminergic neurons. Further investigation indicated that compound 63 could promote the expression of Nurr1 and inhibit neuronal apoptosis signaling pathways.Lead compounds from marine corals exerted significant neuroprotective effects， which indicated that coral might be a new and potential resource for screening and isolating novel natural compounds with neuroprotective effects. Furthermore, this study also provided a new strategy for the clinical treatment of neurodegenerative diseases such as Parkinson's disease.
Databáze: OpenAIRE
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