Molecular characterization of rabies virus isolates in China during 2004
| Autor: | Zhen F. Fu, Dingming Wang, Zong-Yu Hao, Qi-You Xiao, Ling-Zhu Zhang, Yang Zou, Ren-Jie Jiang, Yong-Xin Yu, Yong-Zhen Zhang, Chenglong Xiong |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
China Population Sequence Homology Biology medicine.disease_cause Dogs Phylogenetics Virology medicine Animals Humans education Gene Phylogeny education.field_of_study Molecular Epidemiology Molecular epidemiology Phylogenetic tree Rabies virus Nucleocapsid Proteins medicine.disease Nucleoprotein Infectious Diseases RNA Viral Rabies |
| Zdroj: | Virus research. 121(2) |
| ISSN: | 0168-1702 |
| Popis: | Human rabies cases have been on the rise during the past few years in China and a total of 2651 cases were reported in 2004. To better understand the current rabies epidemics in China, we isolated rabies viruses from dogs and humans from five provinces and characterized these isolates genetically by sequencing the entire nucleoprotein (N) gene. Comparison of the N genes among these isolates revealed 86.6-99.9% homology and these viruses can be grouped into three lineages. Phylogenetic analysis indicates that all the Chinese isolates have a close relationship with viruses circulating in Asian canine population. When compared with rabies viruses isolated previously, the three lineages were similar to three of the four groups. Thus, our data suggest that rabies viruses currently circulating in China were similar, if not identical, to those reported in the previous epidemics. |
| Databáze: | OpenAIRE |
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