The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions

Autor:	Masanori Wakisaka, Kuniyuki Nakamura, Takanari Kitazono
Rok vydání:	2022
Předmět:	Endocrinology Glucose Sodium-Glucose Transporter 2 Ischemia Endocrinology Diabetes and Metabolism Mesangial Cells Sodium Internal Medicine Diabetes Mellitus Humans General Medicine Pericytes Capillaries
Zdroj:	Diabetes research and clinical practice. 192
ISSN:	1872-8227
Popis:	SGLT2 is expressed in mesangial cells and pericytes, and is upregulated byhigh glucose and ischemia. Upregulated SGLT2 in both cells might directly worsen ischemia in kidney interstitial legion, heart and brain. The overexpression of SGLT2 in these cells could induce various organ failures via damages or loss of capillaries and dysfunctions of mesangial cells, which are attenuated by SGLT2 inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d95282a373267b2afbd6c1600771d8 https://pubmed.ncbi.nlm.nih.gov/36174778 Zobrazit plný text záznamu Full Text from ScienceDirect