Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent
| Autor: | Ke-Yu Chen, Xiao-Ming Zhang, Pan Li, Zhu Jiang, Zhi-Yang Xia, Chengyi Shen, Qian Xia, Tao Cheng, Chunrong Zhu, Lei Zhong, Bin Xiao, Changqiang Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Biodistribution
Cell Survival MRI contrast agent Contrast Media Ethylenediaminetetraacetic acid 01 natural sciences Cell Line Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Mice In vivo Coordination Complexes Drug Discovery Amphiphile medicine Animals Humans Tissue Distribution Edetic Acid 030304 developmental biology 0303 health sciences Manganese medicine.diagnostic_test biology Molecular Structure Magnetic resonance imaging Ligand (biochemistry) Magnetic Resonance Imaging 0104 chemical sciences Rats 010404 medicinal & biomolecular chemistry chemistry biology.protein Biophysics Hepatocytes Molecular Medicine Hydrophobic and Hydrophilic Interactions Organic anion |
| Zdroj: | Journal of medicinal chemistry. 64(13) |
| ISSN: | 1520-4804 |
| Popis: | Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Bromosulfophthalein (BSP) inhibition imaging, biodistribution, and cellular uptake studies confirmed that the mechanism of hepatic targeting of Mn-BnO-TyrEDTA is the hepatic uptake of the amphiphilic anion contrast agent mediated by organic anion transporting polypeptides (OATPs) expressed by functional hepatocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|