Genetic influences on functional connectivity associated with feedback processing and prediction error: Phase coupling of theta-band oscillations in twins

Autor: Simon Golosheykin, Andrey P. Anokhin, Şükrü Barış Demiral
Rok vydání: 2015
Předmět:
Male
Time Factors
Adolescent
Decision Making
Individuality
Electroencephalography
Gyrus Cinguli
050105 experimental psychology
Article
Developmental psychology
03 medical and health sciences
Young Adult
0302 clinical medicine
Physiology (medical)
Negative feedback
Synchronization (computer science)
medicine
Twins
Dizygotic
Humans
0501 psychology and cognitive sciences
Theta Rhythm
Anterior cingulate cortex
Genetic Association Studies
Neural correlates of consciousness
Principal Component Analysis
medicine.diagnostic_test
General Neuroscience
05 social sciences
Twins
Monozygotic
Neurofeedback
Network dynamics
Phase synchronization
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Games
Experimental
Female
Abnormality
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 115
ISSN: 1872-7697
Popis: Detection and evaluation of the mismatch between the intended and actually obtained result of an action (reward prediction error) is an integral component of adaptive self-regulation of behavior. Extensive human and animal research has shown that evaluation of action outcome is supported by a distributed network of brain regions in which the anterior cingulate cortex (ACC) plays a central role, and the integration of distant brain regions into a unified feedback-processing network is enabled by long-range phase synchronization of cortical oscillations in the theta band. Neural correlates of feedback processing are associated with individual differences in normal and abnormal behavior, however, little is known about the role of genetic factors in the cerebral mechanisms of feedback processing. Here we examined genetic influences on functional cortical connectivity related to prediction error in young adult twins (age 18, n = 399) using event-related EEG phase coherence analysis in a monetary gambling task. To identify prediction error-specific connectivity pattern, we compared responses to loss and gain feedback. Monetary loss produced a significant increase of theta-band synchronization between the frontal midline region and widespread areas of the scalp, particularly parietal areas, whereas gain resulted in increased synchrony primarily within the posterior regions. Genetic analyses showed significant heritability of frontoparietal theta phase synchronization (24 to 46%), suggesting that individual differences in large-scale network dynamics are under substantial genetic control. We conclude that theta-band synchronization of brain oscillations related to negative feedback reflects genetically transmitted differences in the neural mechanisms of feedback processing. To our knowledge, this is the first evidence for genetic influences on task-related functional brain connectivity assessed using direct real-time measures of neuronal synchronization.
Databáze: OpenAIRE
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