Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum
| Autor: | Efrain C. Azmitia, M. F. Alzoobaee, Z. T. Saccomano, Patricia M. Whitaker-Azmitia, Maura Boldrini |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine Cerebellum Adolescent Autism Spectrum Disorder Angiogenesis Antigens CD34 Auditory cortex Article Nestin Young Adult 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) Developmental and Educational Psychology medicine Humans Child Cerebral Cortex Temporal cortex Neovascularization Pathologic Brain Infant Immunohistochemistry Pons 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex Child Preschool Female Psychology Neuroscience Biomarkers 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Journal of Autism and Developmental Disorders. 46:1307-1318 |
| ISSN: | 1573-3432 0162-3257 |
| DOI: | 10.1007/s10803-015-2672-6 |
| Popis: | In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding. |
| Databáze: | OpenAIRE |
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