Estudo das condições reacionais da reação de clivagem oxidativa de β-hidróxi éteres bicíclicos promovida por tetróxido de rutênio

Autor:	Helena M. C. Ferraz, Alexsandra Cristina Scalfo, Luiz S. Longo, Bruno T. Vilalba
Jazyk:	portugalština
Rok vydání:	2010
Předmět:	Solvent system Chlorinated solvents Sodium periodate General Chemistry medium ring lactones Ring (chemistry) Medicinal chemistry oxidative cleavage chemistry.chemical_compound chemistry Ruthenium tetraoxide ruthenium tetraoxide Organic chemistry Ruthenium trichloride Oxidative cleavage
Zdroj:	Química Nova v.33 n.10 2010 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Volume: 33, Issue: 10, Pages: 2113-2117, Published: 2010
Popis:	A systematic study of the reaction of β-hydroxy ethers with ruthenium tetraoxide (RuO4), generated in situ from ruthenium trichloride and sodium periodate, is presented, leading to nine-membered ring keto-lactones in moderate yields. Three different solvent systems - AcOEt/MeCN/H2O, MeCN/H2O and DMC/H2O - were studied leading to the desired products in lower yields than those obtained with the classical mixture of CCl4/MeCN/H2O, commonly used in reactions promoted by this oxidant. However, it is noteworthy that these new solvent systems represent greener alternatives to the chlorinated solvents used in the oxidative cleavage of β-hydroxy ethers by RuO4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d5fcae5395ae941eb735a9aa1a2e17 http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000021 Zobrazit plný text záznamu