Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children
| Autor: | İlker Devrim, Murat Muhtar Yılmazer, Barış Güven, Ozgur Carti, Timur Meşe, Vedide Tavli, Talat Tavli, Banu Kucukemre Aydin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Waist Adolescent Brachial Artery Turkey Statistics Nonparametric Body Mass Index Risk Factors Internal medicine medicine.artery Hyperlipidemia Hyperinsulinemia Medicine Humans cardiovascular diseases Obesity Risk factor Brachial artery Child Ultrasonography Hypertriglyceridemia Chi-Square Distribution business.industry nutritional and metabolic diseases Reproducibility of Results medicine.disease Atherosclerosis Endocrinology Carotid Arteries Intima-media thickness Pediatrics Perinatology and Child Health cardiovascular system Cardiology Linear Models Female business Tunica Intima Body mass index Biomarkers |
| Zdroj: | European journal of pediatrics. 169(10) |
| ISSN: | 1432-1076 |
| Popis: | Obesity is associated with a number of risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension, and early atherosclerosis. Evidence indicates that atherosclerosis begins in childhood and progresses over decades. In this work, we examined the relationship between cardiovascular risk factors and ultrasonographic signs of subclinical atherosclerosis in 77 obese children and adolescents compared to 40 non-obese healthy peers. Carotis intima media thickness (cIMT), carotid artery compliance (CAC), brachial artery flow-mediated dilatation (FMD), and established cardiovascular risk factors were studied. In the obese patients, cIMT was significantly increased (0.57 mm vs 0.45 mm, p < 0.001) whereas CAC (1.84% vs 3.29%, p < 0.001) and FMD (9.67 % vs 14.81%, p < 0.001) were significantly decreased. In multiple linear regression analysis, a relation was observed between cIMT, CAC, brachial FMD on one hand, and body mass index (BMI) on the other. Among the lipid anomalies, only hypertriglyceridemia was found to be positively correlated with cIMT. Additionally, we found a significant association between waist circumference (WC) and FMD. These findings indicate that obesity in children is associated with arterial wall alterations and endothelial dysfunction. In hyperlipidemic situations, only hypertriglyceridemia was found to be positively correlated with cIMT. This finding has consistently indicated TG to be a risk factor for the development of atherosclerosis. To our knowledge this is the first study to determine the relation between FMD and WC, which is used as a parameter of obesity in childhood. |
| Databáze: | OpenAIRE |
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