Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia
| Autor: | Soefjan Tsauri, J. M. Pezzuto, A. D. Kinghorn, Leonardus B.S. Kardono, Kosasih Padmawinata |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Magnetic Resonance Spectroscopy
Iridoid Stereochemistry medicine.drug_class Pharmaceutical Science Pharmacognosy Lignin Lignans Analytical Chemistry chemistry.chemical_compound Lactones Glucosides Drug Discovery medicine Benzoquinones Tumor Cells Cultured Animals Humans Iridoids Furans Pyrans Pharmacology chemistry.chemical_classification Lignan Plants Medicinal biology Apocynaceae Molecular Structure Leukemia P388 Organic Chemistry Liriodendrin Quinones Glycoside biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Indenes visual_art visual_art.visual_art_medium Molecular Medicine Bark Drug Screening Assays Antitumor Plumeria rubra |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0163-3864 |
| Popis: | By bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra collected in Indonesia. Three iridoids, fulvoplumierin [1], allamcin [2], and allamandin [3], as well as 2,5-dimethoxy-p-benzoquinone [4], were found to be active constituents of the P. rubra petroleum-ether- and CHCl3-soluble extracts. Cytotoxic compounds isolated from the H2O-soluble extract of the bark were the iridoid plumericin [5], and the lignan liriodendrin [6]. Each of these substances was found to demonstrate general cytotoxic activity when evaluated with a panel of cell lines composed of murine lymphocytic leukemia (P-388) and a number of human cancer cell-types (breast, colon, fibrosarcoma, lung, melanoma, KB). Five additional iridoids, 15-demethylplumieride [7], plumieride [8], alpha-allamcidin [9], beta-allamcidin [10], and 13-O-trans-p-coumaroylplumieride [11], were obtained as inactive constituents. Compound 7 was found to be a novel natural product, and its structure was determined by spectroscopic methods and by conversion to plumieride [8]. The configuration of the C-4 stereocenter was unambiguously assigned for compounds 9 and 10, and certain nmr reassignments have been provided for compound 1. |
| Databáze: | OpenAIRE |
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