Testes size and testosterone levels in a model for weightlessness
| Autor: | J. E. Royland, L.J. Weber, M. Fitzpatrick |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Microgram Biology Testicle General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Eating Internal medicine Testis medicine Animals Testosterone General Pharmacology Toxicology and Pharmaceutics Total Tissue Weightlessness Body Weight Skeletal muscle Organ Size General Medicine Muscle atrophy Rats medicine.anatomical_structure Endocrinology Regression Analysis medicine.symptom Hormone |
| Zdroj: | Life Sciences. 54:545-554 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(94)90005-1 |
| Popis: | The purpose of this study was to test whether the lack of testicular growth found in suspended rats would affect testosterone production in a way that might have consequences on muscle atrophy and function studies. Body and testes weight, food consumption, and testosterone levels in testes and plasma were measured at the beginning of the experiment and after 1, 3 or 8 weeks of suspension. Suspended animals ate more but gained less weight than their pair-fed controls. Testes testosterone concentration (microgram/g tissue) was increased at 3 and 8 weeks, but total tissue testosterone (microgram/testes) was not. Up to 3 weeks of suspension, tissue concentration was dependent on testes size and independent of treatment. Plasma testosterone was increased only after 8 weeks of suspension. At 8 weeks, plasma levels correlated with total testes testosterone. Our results show that use of the Morey-Holton rat tail-suspension model up to 3 weeks did not induce testosterone changes of consequence to a skeletal muscle study. For long term studies consideration should be given to possible hormonal effects as tissue and plasma testosterone levels increase after 8 weeks of suspension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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